Group the controls by purpose
Click the game view to lock the pointer; use the mouse wheel to zoom. Flying-type companions can glide by holding jump.
Approach a Poké Ball, altar, portal or catchable target and press E. C and R are for incense and ultimates, not normal attacks.
Change bindings if needed
Bindings can be changed under Settings → Keys. Choose upgrades with the mouse or number keys 1–4. Reroll, skip and banish default to F, X and Z.